HIRA Antibody
| Code | Size | Price |
|---|
| PSI-58-871-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a histone chaperone that preferentially
places the variant histone H3.3 in nucleosomes. Orthologs of this
gene in yeast, flies, and plants are necessary for the formation of
transcriptionally silent heterochomatin. This gene plays an
important role in the formation of the senescence-associated
heterochromatin foci. These foci likely mediate the irreversible
cell cycle changes that occur in senescent cells. It is considered
the primary candidate gene in some haploinsufficiency syndromes
such as DiGeorge syndrome, and insufficient production of the gene
may disrupt normal embryonic development.
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Banumathy, G., et al. Mol. Cell. Biol. 29(3):758-770(2009)
- Ramelli, G.P., et al. Dev Med Child Neurol 50(12):953-955(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA.
NCBI Gene ID #:
7290
NCBI Official Name:
Protein HIRA
NCBI Official Symbol:
HIRA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
112 kDa
Protein Accession #:
P54198
Protein GI Number:
88984228
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P54198
User NOte:
Optimal dilutions for each application to be determined by the researcher.