DMP1 Antibody
| Code | Size | Price |
|---|
| PSI-60-228-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
Application Note:
For WB starting dilution is: 1:1000
Background:
Dentin matrix acidic phosphoprotein is an extracellular
matrix protein and a member of the small integrin binding ligand
N-linked glycoprotein family. This protein, which is critical for
proper mineralization of bone and dentin, is present in diverse
cells of bone and tooth tissues. The protein contains a large
number of acidic domains, multiple phosphorylation sites, a
functional arg-gly-asp cell attachment sequence, and a DNA binding
domain. In undifferentiated osteoblasts it is primarily a nuclear
protein that regulates the expression of osteoblast-specific genes.
During osteoblast maturation the protein becomes phosphorylated and
is exported to the extracellular matrix, where it orchestrates
mineralized matrix formation. Mutations in the gene are known to
cause autosomal recessive hypophosphatemia, a disease that
manifests as rickets and osteomalacia. The gene structure is
conserved in mammals. Two transcript variants encoding different
isoforms have been described for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
- Turan, S., et al. Bone 46(2):402-409(2010)
- Pereira, R.C., et al. Bone 45(6):1161-1168(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
NCBI Gene ID #:
1758
NCBI Official Name:
Dentin matrix acidic phosphoprotein 1
NCBI Official Symbol:
DMP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
Q13316
Protein GI Number:
7673998
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q13316
User NOte:
Optimal dilutions for each application to be determined by the researcher.