ERN2 Antibody
| Code | Size | Price |
|---|
| PSI-62-675-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease, 3126-, ERN2 (HGNC:16942)
Application Note:
For WB starting dilution is: 1:1000
Background:
ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
Background References:
- Iwawaki, T., et al., Nat. Cell Biol. 3(2):158-164 (2001).
- Niwa, M., et al., Cell 99(7):691-702 (1999).
- Wang, X.Z., et al., EMBO J. 17(19):5708-5717 (1998).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.
NCBI Gene ID #:
10595
NCBI Official Name:
Serine/threonine-protein kinase/endoribonuclease IRE2
NCBI Official Symbol:
ERN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
102 kDa
Protein Accession #:
Q76MJ5
Protein GI Number:
327478597
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q76MJ5
User NOte:
Optimal dilutions for each application to be determined by the researcher.