PCGF2 Antibody
| Code | Size | Price |
|---|
| PSI-58-091-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene contains a RING finger
motif and is similar to the polycomb group (PcG) gene products. PcG
gene products form complexes via protein-protein interaction and
maintain the transcription repression of genes involved in
embryogenesis, cell cycles, and tumorigenesis. This protein was
shown to act as a negative regulator of transcription and has tumor
suppressor activity. The expression of this gene was detected in
various tumor cells, but is limited in neural organs in normal
tissues. Knockout studies in mice suggested that this protein may
negatively regulate the expression of different cytokines,
chemokines, and chemokine receptors, and thus plays an important
role in lymphocyte differentiation and migration, as well as in
immune responses.
Background References:
- Jung, J.H., et al. Biochem. Biophys. Res. Commun. 400(4):523-530(2010)
- Zhang, X.W., et al. Mol. Cancer 9, 40 (2010) :
- Wang, W., et al. Int. J. Cancer 125(12):2836-2843(2009)
- Zhang, J., et al. Biochem. Biophys. Res. Commun. 375(2):252-255(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PCGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human PCGF2.
NCBI Gene ID #:
7703
NCBI Official Name:
Polycomb group RING finger protein 2
NCBI Official Symbol:
PCGF2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
P35227
Protein GI Number:
462585
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P35227
User NOte:
Optimal dilutions for each application to be determined by the researcher.