S100B/S-100 Antibody
| Code | Size | Price |
|---|
| PSI-58-108-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, S100B
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the S100
family of proteins containing 2 EF-hand calcium-binding motifs.
S100 proteins are localized in the cytoplasm and/or nucleus of a
wide range of cells, and involved in the regulation of a number of
cellular processes such as cell cycle progression and
differentiation. S100 genes include at least 13 members which are
located as a cluster on chromosome 1q21; however, this gene is
located at 21q22.3. This protein may function in Neurite extension,
proliferation of melanoma cells, stimulation of Ca2+ fluxes,
inhibition of PKC-mediated phosphorylation, astrocytosis and axonal
proliferation, and inhibition of microtubule assembly. Chromosomal
rearrangements and altered expression of this gene have been
implicated in several neurological, neoplastic, and other types of
diseases, including Alzheimer's disease, Down's syndrome, epilepsy,
amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Background References:
- Sahoo, N., et al. FEBS Lett. 584(18):3896-3900(2010)
- Lin, J., et al. J. Biol. Chem. 285(35):27487-27498(2010)
- van Dieck, J., et al. FEBS Lett. 584(15):3269-3274(2010)
- Egberts, F., et al. Anticancer Res. 30(5):1799-1805(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Immunogen:
This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the Central region of human S100B/S-100.
NCBI Gene ID #:
6285
NCBI Official Name:
Protein S100-B
NCBI Official Symbol:
S100B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
11 kDa
Protein Accession #:
P04271
Protein GI Number:
134138
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P04271
User NOte:
Optimal dilutions for each application to be determined by the researcher.