RFFL Antibody
| Code | Size | Price |
|---|
| PSI-60-548-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase rififylin, 632-, Caspase regulator CARP2, Caspases-8 and -10-associated RING finger protein 2, CARP-2, FYVE-RING finger protein Sakura, Fring, RING finger and FYVE-like domain-containing protein 1, RING finger protein 189, RING finger protein 34-like, RFFL (HGNC:24821), RNF189, RNF34L
Application Note:
For WB starting dilution is: 1:1000
Background:
RFFL has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
Background References:
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
- Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)
- Liao, W., et al. Curr. Biol. 18(9):641-649(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This RFFL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human RFFL.
NCBI Gene ID #:
117584
NCBI Official Name:
E3 ubiquitin-protein ligase rififylin
NCBI Official Symbol:
RFFL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
Q8WZ73
Protein GI Number:
74760639
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q8WZ73
User NOte:
Optimal dilutions for each application to be determined by the researcher.