RNF14 Antibody
| Code | Size | Price |
|---|
| PSI-59-350-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase RNF14, 632-, Androgen receptor-associated protein 54, HFB30, RING finger protein 14, Triad2 protein, RNF14, ARA54
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene contains a RING zinc
finger, a motif known to be involved in protein-protein
interactions. This protein interacts with androgen receptor (AR)
and may function as a coactivator that induces AR target gene
expression in prostate. A dominant negative mutant of this gene has
been demonstrated to inhibit the AR-mediated growth of prostate
cancer. This protein also interacts with class III
ubiquitin-conjugating enzymes (E2s) and may act as a
ubiquitin-ligase (E3) in the ubiquitination of certain nuclear
proteins. Five alternatively spliced transcript variants encoding
two distinct isoforms have been reported.
Background References:
- Xu, K., et al. Cancer Cell 15(4):270-282(2009)
- Lan, K.C., et al. Fertil. Steril. 89 (5 SUPPL), 1397-1405 (2008) :
- Kikuchi, H., et al. Carcinogenesis 28(8):1752-1758(2007)
- Yang, Z., et al. Endocrinology 148(3):1340-1349(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RNF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human RNF14.
NCBI Gene ID #:
9604
NCBI Official Name:
E3 ubiquitin-protein ligase RNF14
NCBI Official Symbol:
RNF14
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
Q9UBS8
Protein GI Number:
17380293
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q9UBS8
User NOte:
Optimal dilutions for each application to be determined by the researcher.