CELA3B Antibody
| Code | Size | Price |
|---|
| PSI-57-258-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Elastases form a subfamily of serine proteases that
hydrolyze many proteins in addition to elastin. Humans have six
elastase genes which encode the structurally similar proteins
elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase
3B has little elastolytic activity. Like most of the human
elastases, elastase 3B is secreted from the pancreas as a zymogen
and, like other serine proteases such as trypsin, chymotrypsin and
kallikrein, it has a digestive function in the intestine. Elastase
3B preferentially cleaves proteins after alanine residues. Elastase
3B may also function in the intestinal transport and metabolism of
cholesterol. Both elastase 3A and elastase 3B have been referred to
as protease E and as elastase 1, and excretion of this protein in
fecal material is frequently used as a measure of pancreatic
function in clinical assays.
Background References:
- Gao, J., et al. Oncol. Rep. 23(6):1683-1692(2010)
- Teichmann, J., et al. Eur. J. Med. Res. 13(12):563-567(2008)
- Hahn, J.U., et al. Pancreas 36(3):274-278(2008)
- Mann, S.T., et al. Eur. J. Med. Res. 13(2):68-72(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CELA3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human CELA3B.
NCBI Gene ID #:
23436
NCBI Official Name:
Chymotrypsin-like elastase family member 3B
NCBI Official Symbol:
CELA3B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
P08861
Protein GI Number:
317373457
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P08861
User NOte:
Optimal dilutions for each application to be determined by the researcher.