DAZ4 Antibody
| Code | Size | Price |
|---|
| PSI-56-502-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Deleted in azoospermia protein 4, DAZ4
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene is a member of the DAZ gene family and is a
candidate for the human Y-chromosomal azoospermia factor (AZF). Its
expression is restricted to premeiotic germ cells, particularly in
spermatogonia. It encodes an RNA-binding protein that is important
for spermatogenesis. Four copies of this gene are found on
chromosome Y within palindromic duplications; one pair of genes is
part of the P2 palindrome and the second pair is part of the P1
palindrome. Each gene contains a 2.4 kb repeat including a 72-bp
exon, called the DAZ repeat; the number of DAZ repeats is variable
and there are several variations in the sequence of the DAZ repeat.
Each copy of the gene also contains a 10.8 kb region that may be
amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains two copies of
the 10.8 kb repeat. Alternative splicing results in multiple
transcript variants encoding different isoforms. [provided by
RefSeq].
Background References:
- Kim, B., et al. Hum. Reprod. 24(6):1507-1515(2009)
- Lardone, M.C., et al. Fertil. Steril. 88(5):1318-1326(2007)
- A, Z.C., et al. Yi Chuan 28(9):1057-1060(2006)
- Kuo, P.L., et al. Fertil. Steril. 81(4):1034-1040(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DAZ4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the Central region of human DAZ4.
NCBI Gene ID #:
57135
NCBI Official Name:
Deleted in azoospermia protein 4
NCBI Official Symbol:
DAZ4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65 kDa
Protein Accession #:
Q86SG3
Protein GI Number:
44887840
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q86SG3
User NOte:
Optimal dilutions for each application to be determined by the researcher.