MYOM1 Antibody
| Code | Size | Price |
|---|
| PSI-57-047-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Myomesin-1, 190 kDa connectin-associated protein, 190 kDa titin-associated protein, Myomesin family member 1, MYOM1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The giant protein titin, together with its associated
proteins, interconnects the major structure of sarcomeres, the M
bands and Z discs. The C-terminal end of the titin string extends
into the M line, where it binds tightly to M-band constituents of
apparent molecular masses of 190 kD (myomesin 1) and 165 kD
(myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and
other myofibrillar proteins contains structural modules with strong
homology to either fibronectin type III (motif I) or immunoglobulin
C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique
N-terminal region followed by 12 modules of motif I or motif II, in
the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins
share 50% sequence identity in this repeat-containing region. The
head structure formed by these 2 proteins on one end of the titin
string extends into the center of the M band. The integrating
structure of the sarcomere arises from muscle-specific members of
the superfamily of immunoglobulin-like proteins. Alternatively
spliced transcript variants encoding different isoforms have been
identified.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Schoenauer, R., et al. J. Mol. Biol. 349(2):367-379(2005)
- Hornemann, T., et al. J. Mol. Biol. 332(4):877-887(2003)
- Porter, J.D., et al. J. Exp. Biol. 206 (PT 17), 3101-3112 (2003) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MYOM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904-933 amino acids from the Central region of human MYOM1.
NCBI Gene ID #:
8736
NCBI Official Name:
Myomesin-1
NCBI Official Symbol:
MYOM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
188 kDa
Protein Accession #:
P52179
Protein GI Number:
212276443
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P52179
User NOte:
Optimal dilutions for each application to be determined by the researcher.