SEPSECS Antibody
| Code | Size | Price |
|---|
| PSI-59-861-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48
Application Note:
For WB starting dilution is: 1:1000
Background:
The 21st amino acid, selenocysteine (sec), is distinct
from other amino acids because it lacks its own tRNA synthetase and
is the only amino acid synthesized on its cognate tRNA. Synthesis
of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by
seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec),
which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase
(PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS
catalyzes the final step of sec synthesis by converting
O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using
selenophosphate as the selenium donor (Palioura et al., 2009
[PubMed 19608919]).
Background References:
- Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)
- Hart, K., et al. Lung Cancer (2010) In press :
- Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)
- Palioura, S., et al. Science 325(5938):321-325(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.
NCBI Gene ID #:
51091
NCBI Official Name:
O-phosphoseryl-tRNA(Sec) selenium transferase
NCBI Official Symbol:
SEPSECS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
Q9HD40
Protein GI Number:
62287911
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q9HD40
User NOte:
Optimal dilutions for each application to be determined by the researcher.