SH2D1A Antibody
| Code | Size | Price |
|---|
| PSI-60-808-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that plays a major role in the
bidirectional stimulation of T and B cells. This protein contains
an SH2 domain and a short tail. It associates with the signaling
lymphocyte-activation molecule, thereby acting as an inhibitor of
this transmembrane protein by blocking the recruitment of the
SH2-domain-containing signal-transduction molecule SHP-2 to its
docking site. This protein can also bind to other related surface
molecules that are expressed on activated T, B and NK cells,
thereby modifying signal transduction pathways in these cells.
Mutations in this gene cause lymphoproliferative syndrome X-linked
type 1 or Duncan disease, a rare immunodeficiency characterized by
extreme susceptibility to infection with Epstein-Barr virus, with
symptoms including severe mononucleosis and malignant lymphoma.
Multiple transcript variants encoding different isoforms have been
found for this gene.
Background References:
- Ameratunga, R., et al. N. Z. Med. J. 122(1304):46-53(2009)
- Snow, A.L., et al. J. Clin. Invest. 119(10):2976-2989(2009)
- Nagy, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):11966-11971(2009)
- Ostrakhovitch, E.A., et al. Cell. Signal. 21(4):540-550(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SH2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the C-terminal region of human SH2D1A.
NCBI Gene ID #:
4068
NCBI Official Name:
SH2 domain-containing protein 1A
NCBI Official Symbol:
SH2D1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
14 kDa
Protein Accession #:
O60880
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
O60880
User NOte:
Optimal dilutions for each application to be determined by the researcher.