LILRB1 Antibody
| Code | Size | Price |
|---|
| PSI-58-904-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Leukocyte immunoglobulin-like receptor subfamily B member 1, LIR-1, Leukocyte immunoglobulin-like receptor 1, CD85 antigen-like family member J, Immunoglobulin-like transcript 2, ILT-2, Monocyte/macrophage immunoglobulin-like receptor 7, MIR-7, CD85j, LILRB1, ILT2, LIR1, MIR7
Application Note:
For WB starting dilution is: 1:500-1:2000
Background:
This gene is a member of the leukocyte immunoglobulin-like
receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the
subfamily B class of LIR receptors which contain two or four
extracellular immunoglobulin domains, a transmembrane domain, and
two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
motifs (ITIMs). The receptor is expressed on immune cells where it
binds to MHC class I molecules on antigen-presenting cells and
transduces a negative signal that inhibits stimulation of an immune
response. It is thought to control inflammatory responses and
cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different
isoforms have been found for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Davidson, C.L., et al. Hum. Immunol. 71(10):942-949(2010)
- Huang, J., et al. J. Virol. 84(18):9463-9471(2010)
- Godal, R., et al. Biol. Blood Marrow Transplant. 16(5):612-621(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This LILRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the Central region of human LILRB1.
NCBI Gene ID #:
10859
NCBI Official Name:
Leukocyte immunoglobulin-like receptor subfamily B member 1
NCBI Official Symbol:
LILRB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
71 kDa
Protein Accession #:
Q8NHL6
Protein GI Number:
37537910
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q8NHL6
User NOte:
Optimal dilutions for each application to be determined by the researcher.