C4B Antibody
| Code | Size | Price |
|---|
| PSI-57-400-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2
Application Note:
For WB starting dilution is: 1:2000
Background:
This gene encodes the basic form of complement factor 4,
part of the classical activation pathway. The protein is expressed
as a single chain precursor which is proteolytically cleaved into a
trimer of alpha, beta, and gamma chains prior to secretion. The
trimer provides a surface for interaction between the
antigen-antibody complex and other complement components. The alpha
chain may be cleaved to release C4 anaphylatoxin, a mediator of
local inflammation. Deficiency of this protein is associated with
systemic lupus erythematosus. This gene localizes to the major
histocompatibility complex (MHC) class III region on chromosome 6.
Varying haplotypes of this gene cluster exist, such that
individuals may have 1, 2, or 3 copies of this gene. In addition,
this gene exists as a long form and a short form due to the
presence or absence of a 6.4 kb endogenous HERV-K retrovirus in
intron 9.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Fernando, M.M., et al. Hum. Mutat. 31(7):866-874(2010)
- Mostafa, G.A., et al. J. Neuroimmunol. 223 (1-2), 115-119 (2010) :
- Hamad, O.A., et al. J. Immunol. 184(5):2686-2692(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This C4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the Central region of human C4B.
NCBI Gene ID #:
720, 721
NCBI Official Name:
Complement C4-A
NCBI Official Symbol:
C4A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
193 kDa
Protein Accession #:
P0C0L4
Protein GI Number:
476007827
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P0C0L4
User NOte:
Optimal dilutions for each application to be determined by the researcher.