HLA-DPA1 Antibody
| Code | Size | Price |
|---|
| PSI-59-441-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1, HLA-DPA1, HLA-DP1A, HLASB
Application Note:
For WB starting dilution is: 1:1000
Background:
HLA-DPA1 belongs to the HLA class II alpha chain
paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta (DPB) chain, both anchored in the
membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II
molecules are expressed in antigen presenting cells (APC: B
lymphocytes, dendritic cells, macrophages). The alpha chain is
approximately 33-35 kDa and its gene contains 5 exons. Exon one
encodes the leader peptide, exons 2 and 3 encode the two
extracellular domains, exon 4 encodes the transmembrane domain and
the cytoplasmic tail. Within the DP molecule both the alpha chain
and the beta chain contain the polymorphisms specifying the peptide
binding specificities, resulting in up to 4 different molecules.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Varney, M.D., et al. Diabetes 59(8):2055-2062(2010)
- Ovsyannikova, I.G., et al. PLoS ONE(7), E11806 (2010) :
- Mychaleckyj, J.C., et al. Clin Trials(1 SUPPL), S75-S87 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HLA-DPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the C-terminal region of human HLA-DPA1.
NCBI Gene ID #:
3113
NCBI Official Name:
HLA class II histocompatibility antigen, DP alpha 1 chain
NCBI Official Symbol:
HLA-DPA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
P20036
Protein GI Number:
122204
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P20036
User NOte:
Optimal dilutions for each application to be determined by the researcher.