HAVCR2 Antibody
| Code | Size | Price |
|---|
| PSI-60-816-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3
Application Note:
For WB starting dilution is: 1:2000
Background:
CD4 (MIM 186940)-positive T helper lymphocytes can be
divided into types 1 (Th1) and 2 (Th2) on the basis of their
cytokine secretion patterns. Th1 cells and their associated
cytokines are involved in cell-mediated immunity to intracellular
pathogens and delayed-type hypersensitivity reactions, whereas Th2
cells are involved in the control of extracellular helminthic
infections and the promotion of atopic and allergic diseases. The 2
types of cells also cross-regulate the functions of the other. TIM3
is a Th1-specific cell surface protein that regulates macrophage
activation and enhances the severity of experimental autoimmune
encephalomyelitis in mice.
Background References:
- Cao, B., et al. Cancer Immunol. Immunother. 59(12):1851-1857(2010)
- Dorfman, D.M., et al. Hum. Pathol. 41(10):1486-1494(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Dardalhon, V., et al. J. Immunol. 185(3):1383-1392(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.
NCBI Gene ID #:
84868
NCBI Official Name:
Hepatitis A virus cellular receptor 2
NCBI Official Symbol:
HAVCR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
Q8TDQ0
Protein GI Number:
311033536
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q8TDQ0
User NOte:
Optimal dilutions for each application to be determined by the researcher.