RFXANK Antibody
| Code | Size | Price |
|---|
| PSI-58-290-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA-binding protein RFXANK, Ankyrin repeat family A protein 1, Regulatory factor X subunit B, RFX-B, Regulatory factor X-associated ankyrin-containing protein, RFXANK, ANKRA1, RFXB
Application Note:
For WB starting dilution is: 1:1000
Background:
Major histocompatibility (MHC) class II molecules are
transmembrane proteins that have a central role in development and
control of the immune system. The protein encoded by this gene,
along with regulatory factor X-associated protein and regulatory
factor-5, forms a complex that binds to the X box motif of certain
MHC class II gene promoters and activates their transcription. Once
bound to the promoter, this complex associates with the
non-DNA-binding factor MHC class II transactivator, which controls
the cell type specificity and inducibility of MHC class II gene
expression. This protein contains ankyrin repeats involved in
protein-protein interactions. Mutations in this gene have been
linked to bare lymphocyte syndrome type II, complementation group
B. Two transcript variants encoding different isoforms have been
described for this gene, with only one isoform showing activation
activity.
Background References:
- Garvie, C.W., et al. Biochim. Biophys. Acta 1779(12):797-804(2008)
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Krawczyk, M., et al. Mol. Cell. Biol. 25(19):8607-8618(2005)
- Wang, A.H., et al. J. Biol. Chem. 280(32):29117-29127(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RFXANK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human RFXANK.
NCBI Gene ID #:
8625
NCBI Official Name:
DNA-binding protein RFXANK
NCBI Official Symbol:
RFXANK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
O14593
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
O14593
User NOte:
Optimal dilutions for each application to be determined by the researcher.