C4BPB Antibody
| Code | Size | Price |
|---|
| PSI-58-233-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
C4b-binding protein beta chain, C4BPB
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of a superfamily of proteins
composed predominantly of tandemly arrayed short consensus repeats
of approximately 60 amino acids. A single, unique beta-chain
encoded by this gene assembles with seven identical alpha-chains
into the predominant isoform of C4b-binding protein, a multimeric
protein that controls activation of the complement cascade through
the classical pathway. C4b-binding protein has a regulatory role in
the coagulation system also, mediated through the beta-chain
binding of protein S, a vitamin K-dependent protein that serves as
a cofactor of activated protein C. The genes encoding both alpha
and beta chains are located adjacent to each other on human
chromosome 1 in the regulator of complement activation gene
cluster. Alternative splicing gives rise to multiple transcript
variants.
Background References:
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Buil, A., et al. Blood 115(23):4644-4650(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB.
NCBI Gene ID #:
725
NCBI Official Name:
C4b-binding protein beta chain
NCBI Official Symbol:
C4BPB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
P20851
Protein GI Number:
115213
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P20851
User NOte:
Optimal dilutions for each application to be determined by the researcher.