MASP1 Antibody
| Code | Size | Price |
|---|
| PSI-59-666-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Mannan-binding lectin serine protease 1, 3421-, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5, Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, MASP1, CRARF, CRARF1, PRSS5
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a serine protease that functions as a
component of the lectin pathway of complement activation. The
complement pathway plays an essential role in the innate and
adaptive immune response. The encoded protein is synthesized as a
zymogen and is activated when it complexes with the pathogen
recognition molecules of lectin pathway, the mannose-binding lectin
and the ficolins. This protein is not directly involved in
complement activation but may play a role as an amplifier of
complement activation by cleaving complement C2 or by activating
another complement serine protease, MASP-2. The encoded protein is
also able to cleave fibrinogen and factor XIII and may may be
involved in coagulation. A splice variant of this gene which lacks
the serine protease domain functions as an inhibitor of the
complement pathway. Alternate splicing results in multiple
transcript variants.
Background References:
- Kocsis, A., et al. J. Immunol. 185(7):4169-4178(2010)
- Degn, S.E., et al. J. Immunol. Methods 361 (1-2), 37-50 (2010) :
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-507 amino acids from the Central region of human MASP1.
NCBI Gene ID #:
5648
NCBI Official Name:
Mannan-binding lectin serine protease 1
NCBI Official Symbol:
MASP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
79 kDa
Protein Accession #:
P48740
Protein GI Number:
218512135
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P48740
User NOte:
Optimal dilutions for each application to be determined by the researcher.