TDT Antibody
| Code | Size | Price |
|---|
| PSI-57-757-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase, DNTT, TDT
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the DNA polymerase type-X family
and encodes a template-independent DNA polymerase that catalyzes
the addition of deoxynucleotides to the 3'-hydroxyl terminus of
oligonucleotide primers. In vivo, the encoded protein is expressed
in a restricted population of normal and malignant pre-B and pre-T
lymphocytes during early differentiation, where it generates
antigen receptor diversity by synthesizing non-germ line elements
(N-regions) at the junctions of rearranged Ig heavy chain and T
cell receptor gene segments. Alternatively spliced transcript
variants encoding different isoforms of this gene have been
described.
Background References:
- Kubota, T., et al. Genes Cells 12(8):941-959(2007)
- O'Malley, D.P., et al. Haematologica 91(8):1139-1140(2006)
- Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
- Thai, T.H., et al. J. Immunol. 173(6):4009-4019(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This TDT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TDT.
NCBI Gene ID #:
1791
NCBI Official Name:
DNA nucleotidylexotransferase
NCBI Official Symbol:
DNTT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
59 kDa
Protein Accession #:
P04053
Protein GI Number:
311033533
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P04053
User NOte:
Optimal dilutions for each application to be determined by the researcher.