ProSci

ULBP2 Antibody

Product Code:
 
PSI-58-936
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane.
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Western blot analysis of ULBP2 using rabbit polyclonal ULBP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.
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Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis of ULBP2 using rabbit polyclonal ULBP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.

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PSI-58-936-400ul400ul£626.00
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Further Information

Additional Names:
NKG2D ligand 2, N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2, N2DL2, RAET1H
Application Note:
For WB starting dilution is: 1:1000
Background:
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Background References:
  • McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010)
  • Nuckel, H., et al. Leukemia 24(6):1152-1159(2010)
  • Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)
  • Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ULBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human ULBP2.
NCBI Gene ID #:
80328
NCBI Official Name:
NKG2D ligand 2
NCBI Official Symbol:
ULBP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
27 kDa
Protein Accession #:
Q9BZM5
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q9BZM5
User NOte:
Optimal dilutions for each application to be determined by the researcher.