HLA-DPB1 Antibody
| Code | Size | Price |
|---|
| PSI-57-302-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
HLA-DPB belongs to the HLA class II beta chain paralogues.
This class II molecule is a heterodimer consisting of an alpha
(DPA) and a beta chain (DPB), both anchored in the membrane. It
plays a central role in the immune system by presenting peptides
derived from extracellular proteins. Class II molecules are
expressed in antigen presenting cells (APC: B lymphocytes,
dendritic cells, macrophages). The beta chain is approximately
26-28 kDa and its gene contains 6 exons. Exon one encodes the
leader peptide, exons 2 and 3 encode the two extracellular domains,
exon 4 encodes the transmembrane domain and exon 5 encodes the
cytoplasmic tail. Within the DP molecule both the alpha chain and
the beta chain contain the polymorphisms specifying the peptide
binding specificities, resulting in up to 4 different molecules.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Yang, J.H., et al. Tissue Antigens 76(4):282-288(2010)
- Wang, P., et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24(6):261-263(2010)
- Ovsyannikova, I.G., et al. PLoS ONE(7), E11806 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HLA-DPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the Central region of human HLA-DPB1.
NCBI Gene ID #:
3115
NCBI Official Name:
HLA class II histocompatibility antigen, DP beta 1 chain
NCBI Official Symbol:
HLA-DPB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
P04440
Protein GI Number:
122263
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P04440
User NOte:
Optimal dilutions for each application to be determined by the researcher.