CFHR5 Antibody
| Code | Size | Price |
|---|
| PSI-62-009-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Complement factor H-related protein 5, FHR-5, CFHR5, CFHL5, FHR5
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
CFHR5 is a member of a small complement factor H (CFH)
gene cluster on chromosome 1. Each member of this gene family
contains multiple short consensus repeats (SCRs) typical of
regulators of complement activation. The protein encoded by this
gene has nine SCRs with the first two repeats having heparin
binding properties, a region within repeats 5-7 having heparin
binding and C reactive protein binding properties, and the
C-terminal repeats being similar to a complement component 3 b
(C3b) binding domain. This protein co-localizes with C3, binds C3b
in a dose-dependent manner, and is recruited to tissues damaged by
C-reactive protein. Allelic variations in this gene have been
associated, but not causally linked, with two different forms of
kidney disease: membranoproliferative glomerulonephritis type II
(MPGNII) and hemolytic uraemic syndrome (HUS). [provided by
RefSeq].
Background References:
- McRae, J.L., et al. Genetica 114(2):157-161(2002)
- Murphy, B., et al. Am. J. Kidney Dis. 39(1):24-27(2002)
- Narkio-Makela, M., et al. Clin. Immunol. 100(1):118-126(2001)
- McRae, J.L., et al. J. Biol. Chem. 276(9):6747-6754(2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.
NCBI Gene ID #:
81494
NCBI Official Name:
Complement factor H-related protein 5
NCBI Official Symbol:
CFHR5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
Q9BXR6
Protein GI Number:
23396597
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q9BXR6
User NOte:
Optimal dilutions for each application to be determined by the researcher.