KIR2DS3 Antibody
| Code | Size | Price |
|---|
| PSI-62-042-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Killer cell immunoglobulin-like receptor 2DS3, MHC class I NK cell receptor, Natural killer-associated transcript 7, NKAT-7, KIR2DS3, NKAT7
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
Killer cell immunoglobulin-like receptors (KIRs) are
transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly
homologous and they are found in a cluster on chromosome 19q13.4
within the 1 Mb leukocyte receptor complex (LRC). The gene content
of the KIR gene cluster varies among haplotypes, although several
'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of
extracellular immunoglobulin domains (2D or 3D) and by whether they
have a long (L) or short (S) cytoplasmic domain. KIR proteins with
the long cytoplasmic domain transduce inhibitory signals upon
ligand binding via an immune tyrosine-based inhibitory motif
(ITIM), while KIR proteins with the short cytoplasmic domain lack
the ITIM motif and instead associate with the TYRO protein tyrosine
kinase binding protein to transduce activating signals. The ligands
for several KIR proteins are subsets of HLA class I molecules;
thus, KIR proteins are thought to play an important role in
regulation of the immune response.
Background References:
- Valiante, N.M., et al. Immunity 7(6):739-751(1997)
- Bottino, C., et al. Eur. J. Immunol. 26(8):1816-1824(1996)
- Dohring, C., et al. Immunogenetics 44(3):227-230(1996)
- Wagtmann, N., et al. Immunity 2(5):439-449(1995)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This KIR2DS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3.
NCBI Gene ID #:
3808
NCBI Official Name:
Killer cell immunoglobulin-like receptor 2DS3
NCBI Official Symbol:
KIR2DS3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
34 kDa
Protein Accession #:
Q14952
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q14952
User NOte:
Optimal dilutions for each application to be determined by the researcher.