DEFA3 Antibody
| Code | Size | Price |
|---|
| PSI-60-421-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3
Application Note:
For WB starting dilution is: 1:1000
Background:
Defensins are a family of microbicidal and cytotoxic
peptides thought to be involved in host defense. They are abundant
in the granules of neutrophils and also found in the epithelia of
mucosal surfaces such as those of the intestine, respiratory tract,
urinary tract, and vagina. Members of the defensin family are
highly similar in protein sequence and distinguished by a conserved
cysteine motif. The protein encoded by this gene, defensin, alpha
3, is found in the microbicidal granules of neutrophils and likely
plays a role in phagocyte-mediated host defense. Several alpha
defensin genes are clustered on chromosome 8. This gene differs
from defensin, alpha 1 by only one amino acid. This gene and the
gene encoding defensin, alpha 1 are both subject to copy number
variation.
Background References:
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Chen, Q., et al. Anesthesiology 112(6):1428-1434(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
- Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the C-terminal region of human DEFA3.
NCBI Gene ID #:
1668
NCBI Official Name:
Neutrophil defensin 3
NCBI Official Symbol:
DEFA3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
10 kDa
Protein Accession #:
P59666
Protein GI Number:
30316323
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,
Swissprot #:
P59666
User NOte:
Optimal dilutions for each application to be determined by the researcher.