HLA-C Antibody
| Code | Size | Price |
|---|
| PSI-59-490-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7, HLA-C, HLAC
Application Note:
For WB starting dilution is: 1:1000
Background:
HLA-C belongs to the HLA class I heavy chain paralogues.
This class I molecule is a heterodimer consisting of a heavy chain
and a light chain (beta-2 microglobulin). The heavy chain is
anchored in the membrane. Class I molecules play a central role in
the immune system by presenting peptides derived from endoplasmic
reticulum lumen. They are expressed in nearly all cells. The heavy
chain is approximately 45 kDa and its gene contains 8 exons. Exon
one encodes the leader peptide, exons 2 and 3 encode the alpha1 and
alpha2 domain, which both bind the peptide, exon 4 encodes the
alpha3 domain, exon 5 encodes the transmembrane region, and exons 6
and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and
exon 3 are responsible for the peptide binding specificity of each
class one molecule. Typing for these polymorphisms is routinely
done for bone marrow and kidney transplantation. Over one hundred
HLA-C alleles have been described
Background References:
- Martin, M.P., et al. Immunogenetics 62 (11-12), 761-765 (2010) :
- Strange, A., et al. Nat. Genet. 42(11):985-990(2010)
- Noble, J.A., et al. Diabetes 59(11):2972-2979(2010)
- Honeyborne, I., et al. J. Virol. 84(21):11279-11288(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HLA-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
NCBI Gene ID #:
3107
NCBI Official Name:
HLA class I histocompatibility antigen, Cw-7 alpha chain
NCBI Official Symbol:
HLA-C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
P10321
Protein GI Number:
84028168
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,
Swissprot #:
P10321
User NOte:
Optimal dilutions for each application to be determined by the researcher.