OPTN Antibody
| Code | Size | Price |
|---|
| PSI-59-579-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the coiled-coil containing protein
optineurin. Optineurin may play a role in normal-tension glaucoma
and adult-onset primary open angle glaucoma. Optineurin interacts
with adenovirus E3-14.7K protein and may utilize tumor necrosis
factor-alpha or Fas-ligand pathways to mediate apoptosis,
inflammation or vasoconstriction. Optineurin may also function in
cellular morphogenesis and membrane trafficking, vesicle
trafficking, and transcription activation through its interactions
with the RAB8, huntingtin, and transcription factor IIIA proteins.
Alternative splicing results in multiple transcript variants
encoding the same protein.
Background References:
- McDonald, K.K., et al. J. Hum. Genet. 55(10):697-700(2010)
- Cheng, J.W., et al. Med. Sci. Monit. 16 (8), CR369-CR377 (2010) :
- Albagha, O.M., et al. Nat. Genet. 42(6):520-524(2010)
- Maruyama, H., et al. Nature 465(7295):223-226(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
NCBI Gene ID #:
10133
NCBI Official Name:
Optineurin
NCBI Official Symbol:
OPTN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Protein Accession #:
Q96CV9
Protein GI Number:
317373403
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Neuroscience,Signal Transduction
Swissprot #:
Q96CV9
User NOte:
Optimal dilutions for each application to be determined by the researcher.