CD11b Antibody
| Code | Size | Price |
|---|
| PSI-55-325-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A
Application Note:
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:500
For FACS starting dilution is: 1:10~50
For WB starting dilution is: 1:500
For FACS starting dilution is: 1:10~50
Background:
CD11b is the integrin alpha M chain. Integrins
are heterodimeric integral membrane proteins composed of an alpha
chain and a beta chain. This I-domain containing alpha integrin
combines with the beta 2 chain (ITGB2) to form a leukocyte-specific
integrin referred to as macrophage receptor 1 ('Mac-1'), or
inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2
integrin is important in the adherence of neutrophils and monocytes
to stimulated endothelium, and also in the phagocytosis of
complement coated particles.
Background References:
- Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Warchol, T., et al. DNA Cell Biol. (2010) In press :
- Fan, Y., et al.Eur Acad Dermatol Venereol (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CD11b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the N-terminal region of human CD11b.
NCBI Gene ID #:
3684
NCBI Official Name:
Integrin alpha-M
NCBI Official Symbol:
ITGAM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
127 kDa
Protein Accession #:
P11215
Protein GI Number:
1708572
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Neuroscience,Signal Transduction
Swissprot #:
P11215
User NOte:
Optimal dilutions for each application to be determined by the researcher.