GAD1 Antibody
| Code | Size | Price |
|---|
| PSI-55-719-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes one of several forms of glutamic acid
decarboxylase, identified as a major autoantigen in
insulin-dependent diabetes. The enzyme encoded is responsible for
catalyzing the production of gamma-aminobutyric acid from
L-glutamic acid. A pathogenic role for this enzyme has been
identified in the human pancreas since it has been identified as an
autoantigen and an autoreactive T cell target in insulin-dependent
diabetes. This gene may also play a role in the stiff man syndrome.
Deficiency in this enzyme has been shown to lead to pyridoxine
dependency with seizures. Alternative splicing of this gene results
in two products, the predominant 67-kD form and a less-frequent
25-kD form.
Background References:
- Lanoue, A.C., et al. Exp. Neurol. 226(1):207-217(2010)
- Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
- Terranova, C., et al. Alcohol 44(5):407-413(2010)
- Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-543 amino acids from the C-terminal region of human GAD1.
NCBI Gene ID #:
2571
NCBI Official Name:
Glutamate decarboxylase 1
NCBI Official Symbol:
GAD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
67 kDa
Protein Accession #:
Q99259
Protein GI Number:
1352213
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Obesity,Neuroscience,Signal Transduction
Swissprot #:
Q99259
User NOte:
Optimal dilutions for each application to be determined by the researcher.