HAMP Antibody
| Code | Size | Price |
|---|
| PSI-63-955-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1
Application Note:
For WB starting dilution is: 1:500
Background:
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
Background References:
- Matsumoto, M., et al. Circ. J. 74(2):301-306(2010)
- del Giudice, E.M., et al. J. Clin. Endocrinol. Metab. 94(12):5102-5107(2009)
- Kwapisz, J., et al.Zhejiang Univ Sci10(11):791-795(2009)
- Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the Central region of human HAMP.
NCBI Gene ID #:
57817
NCBI Official Name:
Hepcidin
NCBI Official Symbol:
HAMP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
9 kDa
Protein Accession #:
P81172
Protein GI Number:
10720397
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Obesity,Signal Transduction
Swissprot #:
P81172
User NOte:
Optimal dilutions for each application to be determined by the researcher.