ITGAL Antibody
| Code | Size | Price |
|---|
| PSI-57-204-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Application Note:
For WB starting dilution is: 1:1000
Background:
ITGAL encodes the integrin alpha L chain. Integrins are
heterodimeric integral membrane proteins composed of an alpha chain
and a beta chain. This I-domain containing alpha integrin combines
with the beta 2 chain (ITGB2) to form the integrin lymphocyte
function-associated antigen-1 (LFA-1), which is expressed on all
leukocytes. LFA-1 plays a central role in leukocyte intercellular
adhesion through interactions with its ligands, ICAMs 1-3
(intercellular adhesion molecules 1 through 3), and also functions
in lymphocyte costimulatory signaling. Two transcript variants
encoding different isoforms have been found for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Kuwano, Y., et al. Blood 116(4):617-624(2010)
- Ghannam, S., et al. J. Immunol. 185(1):302-312(2010)
- Quist, S.R., et al. Acta Derm. Venereol. 90(4):429-430(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ITGAL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 722-751 amino acids from the Central region of human ITGAL.
NCBI Gene ID #:
3683
NCBI Official Name:
Integrin alpha-L
NCBI Official Symbol:
ITGAL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
129 kDa
Protein Accession #:
P20701
Protein GI Number:
88911345
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P20701
User NOte:
Optimal dilutions for each application to be determined by the researcher.