OSCAR Antibody
| Code | Size | Price |
|---|
| PSI-60-164-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, hOSCAR, Polymeric immunoglobulin receptor 3, PIgR-3, PIgR3, Poly-Ig receptor 3, OSCAR
Application Note:
For WB starting dilution is: 1:1000
Background:
Osteoclasts are multinucleated cells that resorb bone and
are essential for bone homeostasis. This gene encodes an
osteoclast-associated receptor (OSCAR), which is a member of the
leukocyte receptor complex (LRC) protein family that plays critical
roles in the regulation of both innate and adaptive immune
responses. Different from the other LRC members, OSCAR expression
is detected specifically in preosteoclasts or mature osteoclasts.
OSCAR may be an important bone-specific regulator of osteoclast
differentiation. Multiple alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
Background References:
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
- Herman, S., et al. Arthritis Rheum. 58(10):3041-3050(2008)
- Merck, E., et al. J. Immunol. 176(5):3149-3156(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This OSCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-231 amino acids from the C-terminal region of human OSCAR.
NCBI Gene ID #:
126014
NCBI Official Name:
Osteoclast-associated immunoglobulin-like receptor
NCBI Official Symbol:
OSCAR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
30 kDa
Protein Accession #:
Q8IYS5
Protein GI Number:
311033418
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
Q8IYS5
User NOte:
Optimal dilutions for each application to be determined by the researcher.