FCGR3A Antibody
| Code | Size | Price |
|---|
| PSI-57-101-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a receptor for the Fc portion of
immunoglobulin G, and it is involved in the removal of
antigen-antibody complexes from the circulation, as well as other
other antibody-dependent responses. This gene (FCGR3A) is highly
similar to another nearby gene (FCGR3B) located on chromosome 1.
The receptor encoded by this gene is expressed on natural killer
(NK) cells as an integral membrane glycoprotein anchored through a
transmembrane peptide, whereas FCGR3B is expressed on
polymorphonuclear neutrophils (PMN) where the receptor is anchored
through a phosphatidylinositol (PI) linkage. Mutations in this gene
have been linked to susceptibility to recurrent viral infections,
susceptibility to systemic lupus erythematosus, and alloimmune
neonatal neutropenia. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
Background References:
- Dornan, D., et al. Blood 116(20):4212-4222(2010)
- Li, S.C., et al. Am. J. Hematol. 85(10):810-812(2010)
- Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :
- Qu, Y.H., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):959-962(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FCGR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human FCGR3A.
NCBI Gene ID #:
2214
NCBI Official Name:
Low affinity immunoglobulin gamma Fc region receptor III-A
NCBI Official Symbol:
FCGR3A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
P08637
Protein GI Number:
119876
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P08637
User NOte:
Optimal dilutions for each application to be determined by the researcher.