ITGB2 Antibody
| Code | Size | Price |
|---|
| PSI-59-655-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
Application Note:
For WB starting dilution is: 1:1000
Background:
The product of this gene belongs to the integrin beta
chain family of proteins. Integrins are integral cell-surface
proteins composed of an alpha chain and a beta chain. This gene
encodes the integrin beta chain beta 2. A given chain may combine
with multiple partners resulting in different integrins. For
example, beta 2 combines with the alpha L chain to form the
integrin LFA-1, and combines with the alpha M chain to form the
integrin Mac-1. Integrins are known to participate in cell adhesion
as well as cell-surface mediated signalling. Defects in this gene
are the cause of leukocyte adhesion deficiency type I (LAD1). Two
transcript variants encoding the same protein have been identified
for this gene.
Background References:
- Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010)
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ITGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from the N-terminal region of human ITGB2.
NCBI Gene ID #:
3689
NCBI Official Name:
Integrin beta-2
NCBI Official Symbol:
ITGB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
P05107
Protein GI Number:
124056465
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P05107
User NOte:
Optimal dilutions for each application to be determined by the researcher.