TAPBP Antibody
| Code | Size | Price |
|---|
| PSI-60-069-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding protein, TAPBP, NGS17, TAPA
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a transmembrane glycoprotein which
mediates interaction between newly assembled major
histocompatibility complex (MHC) class I molecules and the
transporter associated with antigen processing (TAP), which is
required for the transport of antigenic peptides across the
endoplasmic reticulum membrane. This interaction is essential for
optimal peptide loading on the MHC class I molecule. Up to four
complexes of MHC class I and this protein may be bound to a single
TAP molecule. This protein contains a C-terminal double-lysine
motif (KKKAE) known to maintain membrane proteins in the
endoplasmic reticulum. This gene lies within the major
histocompatibility complex on chromosome 6. Alternative splicing
results in three transcript variants encoding different isoforms.
Background References:
- Jiang, Q., et al. Tumour Biol. 31(5):451-459(2010)
- Rizvi, S.M., et al. Traffic 11(3):332-347(2010)
- Praveen, P.V., et al. Eur. J. Immunol. 40(1):214-224(2010)
- Barcellos, L.F., et al. PLoS Genet.(10), E1000696 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TAPBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TAPBP.
NCBI Gene ID #:
6892
NCBI Official Name:
Tapasin
NCBI Official Symbol:
TAPBP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
O15533
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
O15533
User NOte:
Optimal dilutions for each application to be determined by the researcher.