CD40 Antibody
| Code | Size | Price |
|---|
| PSI-59-489-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor has been found to be
essential in mediating a broad variety of immune and inflammatory
responses including T cell-dependent immunoglobulin class
switching, memory B cell development, and germinal center
formation. AT-hook transcription factor AKNA is reported to
coordinately regulate the expression of this receptor and its
ligand, which may be important for homotypic cell interactions.
Adaptor protein TNFR2 interacts with this receptor and serves as a
mediator of the signal transduction. The interaction of this
receptor and its ligand is found to be necessary for
amyloid-beta-induced microglial activation, and thus is thought to
be an early event in Alzheimer disease pathogenesis. Two
alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported.
Background References:
- Rodriguez-Rodriguez, L., et al. J. Rheumatol. 37(10):2076-2080(2010)
- Lewis, J.P., et al. Genomics 96(4):211-219(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Blanco-Kelly, F., et al. PLoS ONE(7), E11520 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Pig
Immunogen:
This CD40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human CD40.
NCBI Gene ID #:
958
NCBI Official Name:
Tumor necrosis factor receptor superfamily member 5
NCBI Official Symbol:
CD40
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
P25942
Protein GI Number:
116000
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P25942
User NOte:
Optimal dilutions for each application to be determined by the researcher.