BLNK Antibody
| Code | Size | Price |
|---|
| PSI-57-040-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65, BLNK, BASH, SLP65
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a cytoplasmic linker or adaptor protein
that plays a critical role in B cell development. This protein
bridges B cell receptor-associated kinase activation with
downstream signaling pathways, thereby affecting various biological
functions. The phosphorylation of five tyrosine residues is
necessary for this protein to nucleate distinct signaling effectors
following B cell receptor activation. Mutations in this gene cause
hypoglobulinemia and absent B cells, a disease in which the pro- to
pre-B-cell transition is developmentally blocked. Deficiency in
this protein has also been shown in some cases of pre-B acute
lymphoblastic leukemia. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Oellerich, T., et al. Mol. Cell Proteomics 8(7):1738-1750(2009)
- Imamura, Y., et al. J. Biol. Chem. 284(15):9804-9813(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-82 amino acids from the N-terminal region of human BLNK.
NCBI Gene ID #:
29760
NCBI Official Name:
B-cell linker protein
NCBI Official Symbol:
BLNK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q8WV28
Protein GI Number:
82592659
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Immunology,Signal Transduction
Swissprot #:
Q8WV28
User NOte:
Optimal dilutions for each application to be determined by the researcher.