EPOR Antibody
| Code | Size | Price |
|---|
| PSI-58-645-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Erythropoietin receptor, EPO-R, EPOR
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
This gene encodes the erythropoietin receptor which is a
member of the cytokine receptor family. Upon erythropoietin
binding, this receptor activates Jak2 tyrosine kinase which
activates different intracellular pathways including: Ras/MAP
kinase, phosphatidylinositol 3-kinase and STAT transcription
factors. The stimulated erythropoietin receptor appears to have a
role in erythroid cell survival. Defects in the erythropoietin
receptor may produce erythroleukemia and familial erythrocytosis.
Dysregulation of this gene may affect the growth of certain tumors.
Alternate splicing results in multiple transcript variants.
Background References:
- Lim, A.C., et al. Biochemistry 49(18):3797-3804(2010)
- Perrotta, S., et al. PLoS ONE(8), E12015 (2010) :
- Khankin, E.V., et al. PLoS ONE(2), E9246 (2010) :
- Wincewicz, A., et al. Folia Histochem. Cytobiol. 47(3):425-430(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR.
NCBI Gene ID #:
2057
NCBI Official Name:
Erythropoietin receptor
NCBI Official Symbol:
EPOR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
P19235
Protein GI Number:
119524
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P19235
User NOte:
Optimal dilutions for each application to be determined by the researcher.