PPL Antibody
| Code | Size | Price |
|---|
| PSI-57-532-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Periplakin, 190 kDa paraneoplastic pemphigus antigen, 195 kDa cornified envelope precursor protein, PPL, KIAA0568
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a component of
desmosomes and of the epidermal cornified envelope in
keratinocytes. The N-terminal domain of this protein interacts with
the plasma membrane and its C-terminus interacts with intermediate
filaments. Through its rod domain, this protein forms complexes
with envoplakin. This protein may serve as a link between the
cornified envelope and desmosomes as well as intermediate
filaments. AKT1/PKB, a protein kinase mediating a variety of cell
growth and survival signaling processes, is reported to interact
with this protein, suggesting a possible role for this protein as a
localization signal in AKT1-mediated signaling. [provided by
RefSeq].
Background References:
- Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Pyle, A.L., et al. Cardiovasc. Pathol. 19 (2), E13-E20 (2010) :
- Huang, Y., et al. Arch. Dermatol. Res. 301(10):703-709(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1301-1330 amino acids from the C-terminal region of human PPL.
NCBI Gene ID #:
5493
NCBI Official Name:
Periplakin
NCBI Official Symbol:
PPL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
205 kDa
Protein Accession #:
O60437
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
O60437
User NOte:
Optimal dilutions for each application to be determined by the researcher.