GLRB Antibody
Code | Size | Price |
---|
PSI-58-104-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the beta subunit of the glycine
receptor, which is a pentamer composed of alpha and beta subunits.
The receptor functions as a neurotransmitter-gated ion channel,
which produces hyperpolarization via increased chloride conductance
due to the binding of glycine to the receptor. Mutations in this
gene cause startle disease, also known as hereditary hyperekplexia
or congenital stiff-person syndrome, a disease characterized by
muscular rigidity. Alternative splicing results in multiple
transcript variants.
Background References:
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
- Wheeler, H.E., et al. PLoS Genet.(10), E1000685 (2009) :
- Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380(4):277-291(2009)
- Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of human GLRB.
NCBI Gene ID #:
2743
NCBI Official Name:
Glycine receptor subunit beta
NCBI Official Symbol:
GLRB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
P48167
Protein GI Number:
1346173
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
P48167
User NOte:
Optimal dilutions for each application to be determined by the researcher.