CHRNA2 Antibody
Code | Size | Price |
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PSI-56-130-400ul | 400ul | £626.00 |
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Neuronal acetylcholine receptor subunit alpha-2, CHRNA2
Application Note:
For WB starting dilution is: 1:1000
Background:
Nicotinic acetylcholine receptors (nAChRs) are
ligand-gated ion channels formed by a pentameric arrangement of
alpha and beta subunits to create distinct muscle and neuronal
receptors. Neuronal receptors are found throughout the peripheral
and central nervous system where they are involved in fast synaptic
transmission. This gene encodes an alpha subunit that is widely
expressed in the brain. The proposed structure for nAChR subunits
is a conserved N-terminal extracellular domain followed by three
conserved transmembrane domains, a variable cytoplasmic loop, a
fourth conserved transmembrane domain, and a short C-terminal
extracellular region. Mutations in this gene cause autosomal
dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide
polymorphisms (SNPs) in this gene have been associated with
nicotine dependence.
Background References:
- Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
- Rigbi, A., et al. Pharmacogenomics J. (2010) In press :
- Hoda, J.C., et al. FEBS Lett. 583(10):1599-1604(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2.
NCBI Gene ID #:
1135
NCBI Official Name:
Neuronal acetylcholine receptor subunit alpha-2
NCBI Official Symbol:
CHRNA2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q15822
Protein GI Number:
308153405
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q15822
User NOte:
Optimal dilutions for each application to be determined by the researcher.