KCNA4 Antibody
| Code | Size | Price |
|---|
| PSI-60-814-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L
Application Note:
For WB starting dilution is: 1:1000
Background:
Potassium channels represent the most complex class of
voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating
neurotransmitter release, heart rate, insulin secretion, neuronal
excitability, epithelial electrolyte transport, smooth muscle
contraction, and cell volume. Four sequence-related potassium
channel genes - shaker, shaw, shab, and shal - have been identified
in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six
membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the A-type potassium current class, the
members of which may be important in the regulation of the fast
repolarizing phase of action potentials in heart and thus may
influnce the duration of cardiac action potential. The coding
region of this gene is intronless, and the gene is clustered with
genes KCNA3 and KCNA10 on chromosome 1.
Background References:
- Schwetz, T.A., et al. Biochim. Biophys. Acta 1798(3):367-375(2010)
- Angelova, P.R., et al. Eur. J. Neurosci. 29(10):1943-1950(2009)
- Mckeown, L., et al. J. Biol. Chem. 283(44):30421-30432(2008)
- Lee, J.H., et al. Mol. Pharmacol. 73(3):619-626(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
NCBI Gene ID #:
3739
NCBI Official Name:
Potassium voltage-gated channel subfamily A member 4
NCBI Official Symbol:
KCNA4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
Protein Accession #:
P22459
Protein GI Number:
313104127
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
P22459
User NOte:
Optimal dilutions for each application to be determined by the researcher.