KCNN1 Antibody
| Code | Size | Price |
|---|
| PSI-59-038-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa21, KCNN1, SK
Application Note:
For WB starting dilution is: 1:1000
Background:
Action potentials in vertebrate neurons are followed by an
afterhyperpolarization (AHP) that may persist for several seconds
and may have profound consequences for the firing pattern of the
neuron. Each component of the AHP is kinetically distinct and is
mediated by different calcium-activated potassium channels. The
protein encoded by this gene is activated before membrane
hyperpolarization and is thought to regulate neuronal excitability
by contributing to the slow component of synaptic AHP. The encoded
protein is an integral membrane protein that forms a
voltage-independent calcium-activated channel with three other
calmodulin-binding subunits. This gene is a member of the KCNN
family of potassium channel genes.
Background References:
- Wu, C., et al. Proteomics 7(11):1775-1785(2007)
- Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
- Arnold, S.J., et al. Neuroreport 14(2):191-195(2003)
- Boettger, M.K., et al. Brain 125 (PT 2), 252-263 (2002) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This KCNN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human KCNN1.
NCBI Gene ID #:
3780
NCBI Official Name:
Small conductance calcium-activated potassium channel protein 1
NCBI Official Symbol:
KCNN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q92952
Protein GI Number:
124056468
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q92952
User NOte:
Optimal dilutions for each application to be determined by the researcher.