LRPPRC Antibody
| Code | Size | Price |
|---|
| PSI-61-290-200ul | 200ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Leucine-rich PPR motif-containing protein, mitochondrial, 130 kDa leucine-rich protein, LRP 130, GP130, LRPPRC, LRP130
Application Note:
For WB starting dilution is: 1:2000
Background:
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).
Background References:
- Xu F.,et al.Biochem. J. 382:331-336(2004).
- Ota T.,et al.Nat. Genet. 36:40-45(2004).
- Hillier L.W.,et al.Nature 434:724-731(2005).
- Hou J.,et al.In Vitro Cell. Dev. Biol. Anim. 30A:111-114(1994).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This LRPPRC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1203-1236 amino acids from human LRPPRC.
NCBI Gene ID #:
10128
NCBI Official Name:
Leucine-rich PPR motif-containing protein, mitochondrial
NCBI Official Symbol:
LRPPRC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
158 kDa
Protein Accession #:
P42704
Protein GI Number:
156632706
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
P42704
User NOte:
Optimal dilutions for each application to be determined by the researcher.