RCAN1 Antibody
| Code | Size | Price |
|---|
| PSI-58-724-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1
Application Note:
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
The protein encoded by this gene interacts with
calcineurin A and inhibits calcineurin-dependent signaling
pathways, possibly affecting central nervous system development.
This gene is located in the minimal candidate region for the Down
syndrome phenotype, and is overexpressed in the brain of Down
syndrome fetuses. Chronic overexpression of this gene may lead to
neurofibrillary tangles such as those associated with Alzheimer
disease. Three transcript variants encoding three different
isoforms have been found for this gene.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)
- Lee, M.Y., et al. Hum. Mol. Genet. 19(3):468-479(2010)
- Sales, K.J., et al. Am. J. Pathol. 176(1):435-445(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This RCAN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-68 amino acids from the N-terminal region of human RCAN1.
NCBI Gene ID #:
1827
NCBI Official Name:
Calcipressin-1
NCBI Official Symbol:
RCAN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
P53805
Protein GI Number:
215274235
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
P53805
User NOte:
Optimal dilutions for each application to be determined by the researcher.