RPGR Antibody
Code | Size | Price |
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PSI-56-288-400ul | 400ul | £626.00 |
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
X-linked retinitis pigmentosa GTPase regulator, RPGR, RP3, XLRP3
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a protein with a series of six RCC1-like
domains (RLDs), characteristic of the highly conserved guanine
nucleotide exchange factors. The encoded protein is found in the
Golgi body and interacts with RPGRIP1. This protein localizes to
the outer segment of rod photoreceptors and is essential for their
viability. Mutations in this gene have been associated with
X-linked retinitis pigmentosa (XLRP). Multiple alternatively
spliced transcript variants that encode different isoforms of this
gene have been reported, but the full-length natures of only some
have been determined.
Background References:
- Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
- Schmid, F., et al. Invest. Ophthalmol. Vis. Sci. 51(3):1628-1635(2010)
- Ji, Y., et al. Curr. Eye Res. 35(1):73-79(2010)
- Sheng, X., et al. Mol. Vis. 16, 1620-1628 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RPGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 744-772 amino acids from the C-terminal region of human RPGR.
NCBI Gene ID #:
6103
NCBI Official Name:
X-linked retinitis pigmentosa GTPase regulator
NCBI Official Symbol:
RPGR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
Q92834
Protein GI Number:
23503098
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q92834
User NOte:
Optimal dilutions for each application to be determined by the researcher.