KCNA2 Antibody
| Code | Size | Price |
|---|
| PSI-57-959-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv12, KCNA2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Potassium channels represent the most complex class of
voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating
neurotransmitter release, heart rate, insulin secretion, neuronal
excitability, epithelial electrolyte transport, smooth muscle
contraction, and cell volume. Four sequence-related potassium
channel genes - shaker, shaw, shab, and shal - have been identified
in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six
membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the delayed rectifier class, members of
which allow nerve cells to efficiently repolarize following an
action potential. The coding region of this gene is intronless, and
the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
Background References:
- Denning, E.J., et al. Mol. Membr. Biol. 26(8):397-421(2009)
- Peters, C.J., et al. Channels (Austin) 3(5):314-322(2009)
- Martos, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(26):10482-10486(2009)
- Stirling, L., et al. Mol. Biol. Cell 20(12):2991-3002(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat
Immunogen:
This KCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-479 amino acids from the C-terminal region of human KCNA2.
NCBI Gene ID #:
3737
NCBI Official Name:
Potassium voltage-gated channel subfamily A member 2
NCBI Official Symbol:
KCNA2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
P16389
Protein GI Number:
1345813
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
P16389
User NOte:
Optimal dilutions for each application to be determined by the researcher.