SNAP23 Antibody
Code | Size | Price |
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PSI-57-840-400ul | 400ul | £626.00 |
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Synaptosomal-associated protein 23, SNAP-23, Vesicle-membrane fusion protein SNAP-23, SNAP23
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Specificity of vesicular transport is regulated, in part,
by the interaction of a vesicle-associated membrane protein termed
synaptobrevin/VAMP with a target compartment membrane protein
termed syntaxin. These proteins, together with SNAP25
(synaptosome-associated protein of 25 kDa), form a complex which
serves as a binding site for the general membrane fusion machinery.
Synaptobrevin/VAMP and syntaxin are believed to be involved in
vesicular transport in most, if not all cells, while SNAP25 is
present almost exclusively in the brain, suggesting that a
ubiquitously expressed homolog of SNAP25 exists to facilitate
transport vesicle/target membrane fusion in other tissues. The
protein encoded by this gene is structurally and functionally
similar to SNAP25 and binds tightly to multiple syntaxins and
synaptobrevins/VAMPs. It is an essential component of the high
affinity receptor for the general membrane fusion machinery and is
an important regulator of transport vesicle docking and fusion. Two
alternative transcript variants encoding different protein isoforms
have been described for this gene.
Background References:
- Greaves, J., et al. J. Biol. Chem. 285(32):24629-24638(2010)
- Bostrom, P., et al. Diabetes 59(8):1870-1878(2010)
- Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
- Kean, M.J., et al. J. Cell. Sci. 122 (PT 22), 4089-4098 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SNAP23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-199 amino acids from the C-terminal region of human SNAP23.
NCBI Gene ID #:
8773
NCBI Official Name:
Synaptosomal-associated protein 23
NCBI Official Symbol:
SNAP23
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
O00161
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
O00161
User NOte:
Optimal dilutions for each application to be determined by the researcher.