C10orf2 Antibody
| Code | Size | Price |
|---|
| PSI-56-653-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Twinkle protein, mitochondrial, Progressive external ophthalmoplegia 1 protein, T7 gp4-like protein with intramitochondrial nucleoid localization, T7-like mitochondrial DNA helicase, PEO1, C10orf2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a hexameric DNA helicase which unwinds
short stretches of double-stranded DNA in the 5' to 3' direction
and, along with mitochondrial single-stranded DNA binding protein
and mtDNA polymerase gamma, is thought to play a key role in mtDNA
replication. The protein localizes to the mitochondrial matrix and
mitochondrial nucleoids. Mutations in this gene cause infantile
onset spinocerebellar ataxia (IOSCA) and progressive external
ophthalmoplegia (PEO) and are also associated with several
mitochondrial depletion syndromes. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.
Background References:
- Longley, M.J., et al. J. Biol. Chem. 285(39):29690-29702(2010)
- Wang, W., et al. Nucleic Acids Res. (2010) In press :
- Fratter, C., et al. Neurology 74(20):1619-1626(2010)
- Kruger, J., et al. Mol Neurodegener 5,(2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This C10orf2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-684 amino acids from the C-terminal region of human C10orf2.
NCBI Gene ID #:
56652
NCBI Official Name:
Twinkle protein, mitochondrial
NCBI Official Symbol:
PEO1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
77 kDa
Protein Accession #:
Q96RR1
Protein GI Number:
74752111
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q96RR1
User NOte:
Optimal dilutions for each application to be determined by the researcher.