SERPINI1 Antibody
| Code | Size | Price |
|---|
| PSI-55-159-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
This gene encodes a member of the serpin superfamily of
serine proteinase inhibitors. The protein is primarily secreted by
axons in the brain, and preferentially reacts with and inhibits
tissue-type plasminogen activator. It is thought to play a role in
the regulation of axonal growth and the development of synaptic
plasticity. Mutations in this gene result in familial
encephalopathy with neuroserpin inclusion bodies (FENIB), which is
a dominantly inherited form of familial encephalopathy and epilepsy
characterized by the accumulation of mutant neuroserpin polymers.
Multiple alternatively spliced variants, encoding the same protein,
have been identified.
Background References:
- Takehara, S., et al. J. Mol. Biol. 403(5):751-762(2010)
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
- Davies, M.J., et al. J. Biol. Chem. 284(27):18202-18209(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SERPINI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human SERPINI1.
NCBI Gene ID #:
5274
NCBI Official Name:
Neuroserpin
NCBI Official Symbol:
SERPINI1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
Q99574
Protein GI Number:
3183087
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q99574
User NOte:
Optimal dilutions for each application to be determined by the researcher.